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In Canada – Call your doctor for medical advice about side effects.

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And then there is the plausible argument based on massive Harvard Nurses and Iowa studies that Premarin slightly increases the risk of breast cancer only in women who consume alcohol Zumoff 1998. Some women who have tried both Estrace and Premarin, or the patch and Premarin, decide that they like Premarin better because there is less breast tenderness, whereas pure estradiol feels “too strong.

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But it is Premarin’s supposed superiority when it comes to protection against cardiovascular disease and Alzheimer’s disease that is the central issue here. It has been suggested that horse estrogens are more potent antioxidants when it comes to protecting cholesterol. Subbiah and colleagues 1993 looked at how well various types of estrogens protected LDL cholesterol against oxidation, using the formation of a compound known as malonaldehyde MDA, a lipid peroxidation product, as a measure of antioxidant capacity—the less MDA formed, the better the antioxidant protection.

Here are some figures: Control 21 units of MDA Estrone 14. Here the results were also quite dramatic: Here the results were startling: More recent studies, using different ways of measuring peroxidation, have reached different conclusions.

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